Here is a quick glance of all the highs and lows from Nadal's stupendous career:
Copil, the World No 93, stunned second seed Alexander Zverev of Germany 6-3, 6-7 (6), 6-4 in the day's other semi-final.
Images from Day 10 of the 2021 French Open at Roland Garros in Paris on Tuesday.
The trio have dominated men's tennis over the last 20 years and played a major role in shaping the direction of the sport
Djokovic had been favourite to win a 10th title at Melbourne Park and claim a 21st Grand Slam crown but the Serb now faces being deported from Australia.
American teenage sensation Coco Gauff became the youngest player to win a WTA title in 15 years as she beat former French Open champion Jelena Ostapenko in the Linz Open final on Sunday.
Fans are buzzing over the prospect of a rematch between world number one Alcaraz and second seed Djokovic in a potential New York finale
Images from Day 7 of the 2024 Australian Open in Melbourne on Saturday.
'I'm just glad to overcome today's challenge in straight sets and move on.'
Yuki Bhambri is in line to win his second Challenger level singles title of the season as he advanced to the summit clash after his opponent withdrew due to a lower back problem in Shanghai.
Rafael Nadal is the oldest title winner in the history of the clay-court tournament.
Three-time US Open champion Djokovic, who comes into the tournament having won his fifth Wimbledon title, is followed in the seedings by 2017 winner Rafael Nadal.
Djokovic was soundly beaten by Zverev in the 2018 final, a match played out in an electrifying atmosphere in front of 18,000 fans. This time the arena was empty because of the COVID-19 lockdown, a surreal backdrop for a match with so much riding on it for both men.
Here are a few famous faces that watched Nadal go one step close to matching Roger Federer's 20 Grand Slam titles...
Second seed Daniil Medvedev will launch his bid to win his first major title against veteran Frenchman Richard Gasquet.
World number two Novak Djokovic has withdrawn from the BNP Paribas Open in Indian Wells, the tournament announced on Wednesday, in the latest setback for the player due to his refusal to take the COVID-19 vaccine.
Carlos Alcaraz moved to within two wins of completing the 'Sunshine Double'
With Rafael Nadal out with injury, can Novak Djokovic go past the Spaniard and pick up a record 23rd Grand Slam title.
Andy Murray saved five match points to defeat Jiri Lehecka at the Qatar Open on Friday and reach a first ATP Tour final since June last year.
Tsitsipas had lost all five previous matches against the Russian, but turned the tables in impressive fashion.
Nadal pulled off his greatest escape to deny Daniil Medvedev again, less than three years after leaving the Russian heartbroken in five sets at the 2019 US Open final.
'Let's be confident, let's be positive and let's see what's going on'
Nadal arrived in Paris with his own doctor to get through the tournament despite the injury.
Certainly the prospect of another showdown at the US Open in a few weeks is exciting, but whether or not 23-time Grand Slam champion Djokovic can stretch his career long enough to battle Carlos Alcaraz on a regular basis is questionable.
Pole says she feels much better prepared to handle the pressure of her latest career milestone.
This year's US Open runs from Aug. 28-Sept. 10.
He was drawn in the toughest half of the draw with Nadal as well as in-form Spanish teenager Carlos Alcaraz and world number three Alexander Zverev, who could clash in the last eight.
'It has been unforgettable, and I can only say 'thank you'. It has been an incredible journey. It's very difficult, but life and my body have been sending signals to me for a long time.'
Images from Day 5 of the 2022 French Open at Roland Garros in Paris on Thursday.
With Sunday's win, the world number one took his Grand Slam tally to 18, just two shy of Roger Federer and Rafael Nadal's men's record of 20.
Novak Djokovic is capable of extending his record for holding the men's World No. 1 ranking for most weeks to 400, said Russia's Daniil Medvedev who will climb up to a career-best ranking of second on Monday.
Novak Djokovic marched into the semis of the Dubai Tennis Championship, with a comfortable win over Hubert Hurkacz.
As he continues to live his dream, Novak Djokovic is also staking his claim to the mantle of greatest tennis player of all time.
World No. 1 Novak Djokovic has applied for special permission to enter the United States to participate in the ATP Masters 1000 events.
Novak Djokovic split with his long-time coach Marian Vajda at the end of the 2021 season, ending one of tennis's most enduring and successful partnerships, the Serbian former world number one said.
'I have so much to look forward to in 2021, including the Olympics'
A seemingly invincible Novak Djokovic playing some of the best tennis of his career at 36 heads to Wimbledon seeking to tighten his stranglehold.
No clear favourite for Australian Open, says Djokovic
Organisers are confident a rain-hit opening day will not hold up the tournament.